Adaptyv Nipah glycoprotein G de novo binder competition

Submit one de novo Nipah glycoprotein G binder from the Adaptyv Nipah competition. Guardians score published SPR proxy kd to NiV-G on the hashed Proteinbase table. They do not run SPR or neutralization.

Adaptyv's Nipah Binder Competition asked designers to bind Nipah virus glycoprotein G, a tetramer. 1,196 designs were tested. Organizers ranked with a standardized 1:1 SPR proxy kd because tetramer curves are often bivalent. They also ran ephrin-B2 neutralization on a subset. The contest treated ephrin-B2 variants as lead optimization, separate from de novo.

This bounty purchases the de novo track, not the ephrin lead-opt ranking. It does not purchase a new wet-lab campaign. HuggingFace yk0/proteinbase_interactions is not this snapshot.

Definitions And Scope

A candidate is the amino acid string in binder.fasta. A match is a Proteinbase row whose sequence equals that string. Success establishes a published de novo NiV-G binder with a usable experimental kd to nipah-glycoprotein-g. It does not establish a new physical sample or a neutralization result.

Novelty uses the collection's computational seqidentity evaluation, not a live UniRef50 search.

Required Outputs And Format

binder.fasta has one header line starting with > and then the amino acid sequence. Ignore the header for matching. Concatenate subsequent non-header lines and strip ASCII whitespace. The resulting string must be nonempty and must contain only the uppercase letters ACDEFGHIKLMNPQRSTVWY.

methods.md must contain the matched row's name and author as case-sensitive contiguous substrings. If that row's designMethod is nonempty, methods.md must also contain that designMethod string. It must contain this exact sentence, including the period:

No new laboratory SPR was performed for this Submission.

Package rules:

• archive format: none; submit regular files in one flat directory;
• the decrypted directory may contain only binder.fasta and methods.md.

Access And Known Limitations

The snapshot is 13,590,596 bytes. Guardians fetch it and check SHA-256 of the raw bytes, including a UTF-8 BOM if present, with no decode before hashing. Missing access or a hash mismatch blocks judgment. Kinetic-curve objects inside JSON may contain URLs; do not fetch them.

Parse the hashed bytes as follows. Decode as UTF-8-SIG (BOM stripped for parse only). Then read records with Python 3 csv.reader using the excel dialect and no other options: delimiter is the ASCII comma ,; quote character is "; doublequote is true so a literal " inside a quoted field is encoded as ""; skipinitialspace is false; quoting is csv.QUOTE_MINIMAL. Do not split on commas with a regex, semicolon, or tab. Do not use another dialect.

The first record is the header row. Header cells are the cell text after CSV unquoting. Required header names, each exactly once and in this order: id, name, sequence, author, designMethod, evaluations. Extra columns after those six are ignored. Missing, reordered, or duplicate required headers: the snapshot cannot be used and judgment is blocked.

Every later record is one data row. Map cells to headers by name. If csv.reader raises csv.Error, or a record has fewer fields than the header, skip that record; it is not a data row and cannot match. Extra fields beyond the header are ignored.

The evaluations cell after CSV unquoting is a Unicode string. Decode it with Python 3 json.loads. That turns CSV-unquoted text (where "" has already become ") into JSON. If json.loads raises json.JSONDecodeError, TypeError, or ValueError, or the result is not a JSON array (Python list), that row has no evaluations objects.

• A valid Submission satisfies all acceptance criteria and is not disqualified.
• If multiple Submissions are valid, the Submission with the lowest NiV-G geometric-mean kd wins. Binary64 ties go to the lowercase Solver address that sorts first.
• If no Submission is valid, the outcome is no_valid_submission.

• required artifacts are missing after successful retrieval and decryption;
• an artifact is corrupt or cannot be inspected in its required format;
• the decrypted directory contains any filename other than binder.fasta and methods.md.

Ephrin-B2 lead optimization and organizer controls are already rejected by Pass/Fail Checks 5–7. Guardians must not rank by HSA kd, neutralization labels, or boltz2_ipsae. methods.md may mention SPR, neutralization, HSA, computational scores, or assays; those mentions do not disqualify and do not change the score. Guardians still score only the hashed NiV-G kd set. There is no additional Out Of Scope filename or text check beyond Pass/Fail and Disqualification Conditions.

Allowed Resources And Reuse

Published de novo Nipah designs may be submitted. Disclose name and author.

Each Guardian judges only submitted artifacts, this page, and the listed CSV. Do not run SPR. Do not fetch kinetic-curve URLs.

Evaluation Procedure And Limits

1. Fetch nipah_collection.csv and check its SHA-256.
2. Open binder.fasta and methods.md.
3. Apply Pass/Fail Checks.
4. Geometric-mean NiV-G kd only.
5. Apply the winner rule.

One pass over 1201 rows is enough. Do not train models.