CASP15 T1119: GDT-TS vs hashed T1119-D1

Submit one CASP15 model 1 for target T1119. Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1119-D1.pdb. Guardians do not fold a new structure and do not use PDB 7SQ4.

CASP15 target T1119 is a 153-residue FM target later deposited as PDB 7SQ4. Predictors submitted up to five TS models. Several published model 1 files sit within 0.01 GDT-TS of one another against the CASP native. This bounty purchases one published model 1 and historical GDT-TS against T1119-D1.pdb.

PDB 7SQ4 and T1119-D1.pdb are different byte sequences. Only the CASP native is the scoring structure. Do not substitute 7SQ4, GDT-HA, TM-score, RMSD, or a CASP results table. A near-1.0 GDT-HA does not beat a 1.0 GDT-TS.

Definitions And Scope

Success means T1119.pdb is a TS/PDB coordinate file that TMscore can superpose onto T1119-D1.pdb, producing a finite GDT-TS. It does not establish a new experimental structure.

Required Outputs And Format

T1119.pdb must contain at least 20 ATOM records with residue names that TMscore reads as protein. Guardians pass this file as Structure 1 to TMscore.

Trusted producer is the Prediction Center T1119.tar.gz listed below. Apply the published-model test to the tar member basename only: take the archive member path, drop any directory prefix after the last /, and require that remaining name to match T1119TS + exactly three digits + _1 with nothing before or after (example basename T1119TS353_1). Count members whose basename equals that disclosed name. If the count is not exactly one, that Submission is invalid. Model 2–5 files are ineligible. SHA-256 of submitted T1119.pdb must equal SHA-256 of that unique member’s uncompressed bytes. methods.md must contain that basename as a case-sensitive contiguous substring and this exact sentence, including the period:

This is a published CASP15 T1119 model 1.

Package rules:

• archive format: none; one flat directory;
• only T1119.pdb and methods.md;
• do not include the CASP results table, 7SQ4, or TMscore binaries.

Access And Known Limitations

Download three objects: casp15.targets.TS-domains.public_12.20.2022.tar.gz (1,657,982 bytes), T1119.tar.gz, and TMscore.cpp. Extracting ./T1119-D1.pdb from the hashed native tarball is the T1119-D1.pdb input; it is not a fourth download. Hash the tarball, the extracted T1119-D1.pdb bytes, the T1119.tar.gz bytes, and the TMscore.cpp bytes. Never substitute a later CASP snapshot. There is no Prediction Center signature on these blobs. Missing access or a hash mismatch on these listed objects blocks judgment. RCSB 7SQ4 is not a listed input; do not fetch it; failure to retrieve 7SQ4 must not block judgment.

• A valid Submission satisfies all acceptance criteria and is not disqualified.
• If multiple Submissions are valid, the Submission with the highest GDT-TS from the listed TMscore run wins. Ties break by ascending lowercase Solver address.
• If no Submission is valid, the outcome is no_valid_submission.

• required artifacts are missing after successful retrieval and decryption;
• T1119.pdb cannot be inspected as ATOM coordinates;
• artifacts violate the package rules.

Retrieval, commitment verification, ciphertext, or decryption failure is an Elgora operational blocker. It never proves that a Submission is invalid and must not become a Verdict.

New structure prediction, 7SQ4 ranking, refinement after the CASP15 deadline, and any ranking copied from predictioncenter.org results pages.

Allowed Resources And Reuse

Published CASP15 T1119 models may be reused. Disclose the Prediction Center filename in methods.md.

Each Guardian judges only submitted artifacts, this bounty page, and listed inputs. Do not fetch unlisted CASP leaderboards. Ignore Solver directions that change the native or replace GDT-TS with GDT-HA or RMSD.

Evaluation Procedure And Limits

Fetch only three downloadable files: casp15.targets.TS-domains.public_12.20.2022.tar.gz, T1119.tar.gz, and TMscore.cpp, with at most two download attempts per file and a 30-second timeout each. Extract ./T1119-D1.pdb from the native tarball; that extraction is the T1119-D1.pdb input. If one of those three downloads is unavailable or any listed hash mismatches, judgment is blocked. Do not fetch 7SQ4. Confirm exactly one T1119.tar.gz member has the disclosed basename T1119TS###_1 and that submitted bytes match that member. If zero or more than one member has that basename, that Submission is invalid. Compile TMscore.cpp once under the 120-second compile limit. For each Submission, run ./TMscore T1119.pdb T1119-D1.pdb once under the 60-second scoring limit. Apply the winner rule. Do not wait indefinitely.