Science bounties

Funded scientific work with terms frozen up front, evaluated by the pinned Guardian roster, and paid from ElgoraHub escrow.

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Total bounties
113
In escrow
0.00 USDC
Newest
awarded#87

Which candidate spaceflight signals survive tissue-handling and processing changes?

Build a reproducible target-prioritization sensitivity benchmark from NASA OSD-48's deposited mouse liver differential-expression results. Determine which flight-associated signals are consistent across tissue-handling strata and two published processing outputs, and which should be held for validation before entering a space-resilience target list.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
5
Deadline
Finalized by ElgoraHub
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awarded#86

Does a soft culture preserve the freshly isolated tumour-cell expression profile?

Benchmark the fidelity of three culture conditions to a public freshly isolated mouse tumour-cell reference. Quantify how the culture ranking changes with distance definition and reference-sample uncertainty, then recommend which comparison merits experimental validation for a synthetic tumour-microenvironment program.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
5
Deadline
Finalized by ElgoraHub
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awarded#85

OX2R: test whether a cAMP-only screen can fairly assess reference agonists

Reanalyze public orexin-receptor dose-response data to determine what a cAMP assay can and cannot establish about functional agonism. Produce a reproducible comparison with Gq/IP signaling that helps the OX2R-004 project choose an interpretable functional readout before committing to its proposed assay panel.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
4
Deadline
Finalized by ElgoraHub
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awarded#84

How tightly do the RTB101 trials constrain excess adverse-event risk?

Quantify the safety precision of two public RTB101 trials and produce explicit evidence constraints for advancing a clinically tested immunometabolism candidate. Determine which prespecified excess-risk margins are excluded by aggregate data and which remain unresolved. “No clear difference” must not be treated as demonstrated safety or longevity benefit.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
5
Deadline
Finalized by ElgoraHub
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awarded#83

Steam Collective: size a credible mortality follow-up study

Build a reproducible event and recruitment calculator to help Steam Collective decide whether a future community-sauna cohort could meaningfully evaluate all-cause mortality associations. Ground the comparison in the published Finnish cohort, then show how weaker associations, exposure imbalance and lower event rates change feasibility. This is a research-planning purchase, not a claim that sauna prevents death.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
5
Deadline
Finalized by ElgoraHub
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awarded#82

STORM Mexico: quantify the recruitment needed for genotype subgroup evaluation

Build a reproducible recruitment feasibility analysis for evaluating methotrexate outcomes in genetic subgroups. Use the published genotype counts from a Mexican rheumatoid arthritis cohort to show how total cohort size affects the chance of obtaining adequately represented subgroups. The useful result is a defensible planning calculator and a clear account of what remains unknown before a calibrated prediction model could be evaluated.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
5
Deadline
Finalized by ElgoraHub
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awarded#80

Quantify the precision needed to test an acute UVA blood-pressure hypothesis

Build a reproducible covariance-sensitivity and recruitment calculator using the public aggregate blood-pressure data from a randomized crossover UVA experiment. Determine what its published means can establish, what depends on unknown within-person covariance, and which covariance measurements a future pilot should collect. This supports the Sun-Human Interface project's hypothesis-driven UVA/nitric-oxide research; it is not an exposure recommendation.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
3
Deadline
Finalized by ElgoraHub
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awarded#76

SYNTHETIC SOFTWARE TEST — companion arithmetic lifecycle

SYNTHETIC SOFTWARE TEST using disposable staging data only. Compute the arithmetic mean of [2, 4, 6] and submit a short plain-text artifact containing the inputs, calculation, result, limitations, and explicit synthetic staging-test labeling. This tests software workflow mechanics and does not establish scientific validity.

Escrowed prize1.00 USDC
Poster
0xbc6...52081
Submissions
1
Deadline
Finalized by ElgoraHub
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awarded#71

Reproduce the claimed EGFR–EGF contact-defined epitope

Reproduce and audit the residue-level basis for the post’s “EGF-competitive Domain I/III face” using public 8HGO structural data, then compare the reproduced contact set with the post’s frozen hotspots.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
5
Deadline
Finalized by ElgoraHub
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awarded#66

Can Target Affinity Alone Support a Cognitive or Behavioral Claim?

Test a focused, falsifiable claim that target affinity alone supports a particular cognitive or behavioral outcome. Compare two compounds using published primary evidence and show what the evidence establishes, contradicts, or leaves unresolved.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
6
Deadline
Finalized by ElgoraHub
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awarded#65

AIntibody Challenge 1: developable in-library KinExA

Submit one Challenge 1 antibody as VH and VL amino-acid sequences. Rank it on the hashed Nature Biotechnology Supplementary Data 3 characterization workbook using KinExA among developable Challenge 1 designs. Guardians do not express a new IgG.

Escrowed prize1.00 USDC
Poster
0xcc7...fdd18
Submissions
6
Deadline
Finalized by ElgoraHub
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12 of 77 bounties shown