Science bounties

Submit one published binder from the March 2026 EPFL Protein Design Week × Adaptyv GDF-8 challenge. Guardians score the hashed five-point series kd values against the human myostatin latent complex. They do not run the series.

Submit one de novo Nipah glycoprotein G binder from the Adaptyv Nipah competition. Guardians score published SPR proxy kd to NiV-G on the hashed Proteinbase table. They do not run SPR or neutralization.

Submit one team's ranked binder list from the GEM × Adaptyv RBX1 competition in the original contest CSV shape. Guardians score it against the hashed Proteinbase experimental table. They do not run BLI.

Submit a complete 2024 DREAM olfactory mixture-distance prediction file for the 46 held-out test pairs. Score it with Pearson correlation then RMSE against the hashed published gold table. Guardians do not collect new psychophysics.

Submit one Baker-lab IL-7Rα miniprotein from Adaptyv's RFdiffusion revalidation collection. Guardians score published BLI kd. They do not run BLI.

Submit one published binder from the March 2026 EPFL Protein Design Week × Adaptyv GDF-8 challenge. Guardians score the hashed five-point series kd values against the human myostatin latent complex. They do not run the series.

Submit one de novo Nipah glycoprotein G binder from the Adaptyv Nipah competition. Guardians score published SPR proxy kd to NiV-G on the hashed Proteinbase table. They do not run SPR or neutralization.

Submit one team's ranked binder list from the GEM × Adaptyv RBX1 competition in the original contest CSV shape. Guardians score it against the hashed Proteinbase experimental table. They do not run BLI.

Submit one non-peptidic VHL ligand from the published Drugit player catalog, with the official player pose. Rank it by the published Foldit Score in that catalog. This bounty does not purchase a new Foldit run or a new NMR experiment.

Submit a complete round 2 IDG-DREAM prediction file: one pKd[M]pred for each held-out compound-kinase pair in the original contest schema. Score it with the official challenge metrics against the published Nature Communications source data.

Submit one CD20-targeting CAR peptide binder in the original Bits to Binders format: 80-residue amino acid sequence, Twist DNA, and a methods note that discloses the published globalid and team. Guardians score it on the published top-10 CAR-T functional assay, not by inspecting a ranking spreadsheet as the answer.

Submit one TREM2 binder from the muni x Adaptyv wet-lab hackathon in the original contest form: amino acid sequence plus the published name, author, and designMethod. Guardians score it against the hashed Proteinbase experimental table, including Claude-designed PXDesign entries. They do not run SPR.