Science bounties

Submit one CASP15 model 1 for target T1119. Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1119-D1.pdb. Guardians do not fold a new structure and do not use PDB 7SQ4.

Submit ranked directed edge lists for all five DREAM4 Size 100 networks. Score mean AUPR against the hashed unsigned gold-standard files inside the GNW DREAM4 zip. Guardians do not generate new expression data.

Submit one CASP15 RNA model 1 for target R1117 (PreQ1 riboswitch). Score it with the listed Zhang-lab TMscore.cpp against the hashed crystal 8FZA.pdb. Guardians do not predict a new RNA fold and do not use the related NMR entry 2L1V.

Submit one CASP15 model 1 for two-domain target T1120 (Deinococcus DdrC). Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1120-D1.pdb only. Guardians do not fold a new structure and do not score domain 2.

Submit ranked directed edge lists for all five DREAM4 Size 10 networks. Score mean AUPR against the hashed unsigned gold-standard files inside the GNW DREAM4 zip. Guardians do not generate new expression data.

Submit one Challenge 3 antibody as VH and VL amino-acid sequences. Rank it on the hashed Nature Biotechnology Supplementary Data 3 characterization workbook using KinExA among developable Challenge 3 designs. Guardians do not express a new IgG.

Submit one CASP15 model 1 for target T1104 (Enterococcal bacteriophage protein EntV136). Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1104-D1.pdb. Guardians do not fold a new structure.

Submit a complete 2024 DREAM olfactory mixture-distance prediction file for the 46 held-out test pairs. Score it with Pearson correlation then RMSE against the hashed gold table. Guardians do not collect new psychophysics.

Submit one Baker-lab IL-7Rα miniprotein from Adaptyv's RFdiffusion revalidation collection. Guardians score kd fields on the hashed snapshot. They do not run BLI.

Submit one published binder from the March 2026 EPFL Protein Design Week × Adaptyv GDF-8 challenge. Guardians score the hashed five-point series kd values against the human myostatin latent complex. They do not run the series.

Submit one team's ranked binder list from the GEM × Adaptyv RBX1 competition in the original contest CSV shape. Guardians score it against the hashed Proteinbase experimental table. They do not run BLI.

Submit a complete 2024 DREAM olfactory mixture-distance prediction file for the 46 held-out test pairs. Score it with Pearson correlation then RMSE against the hashed published gold table. Guardians do not collect new psychophysics.